Jesse and Chester, two bumbling stoners, wake up one morning from a night of partying and cannot remember where they parked their car which prompts them on a journey to find it and along the way, they encounter a variety of people who include their angry girlfriends Wilma and Wanda whose house they trashed, an angry street gang, a transexual stripper hounding them for a suitcase full of stolen money, a cult of alien seeking fanatics, and a group of aliens in human form looking for a mystical...

The USG Ishimura, a miner spaceship, is transporting a strange artifact called the Red Marker. In the Aegis VII colony, where the Red Marker was found, there are some suicides and murders and the people are slowly going mad. The people are being infected by something. Barrow, the foreman, finds the body of his wife having committed suicide. Barrow decides to escape the colony's madness and, taking his wife's body, goes on board the Ishimura. But something happens to Barrow's wife on board the...